Since December 2019, the severity of the coronavirus disease 2019 (COVID‐19) pandemic has been escalating. 2 Systemic microvascular thrombosis may occur in most deaths, and was corroborated by a recent autopsy. Background: Over 240000 cases of coronavirus disease-19 (COVID-19) has been reported since Dec. 2019. COVID-19 raises D-dimer (DD) levels even in the absence of pulmonary embolism (PE), resulting in an increase in computed tomography pulmonary angiogram (CTPA) requests. D-dimer levels correlate with disease severity and are a reliable prognostic marker for in-hospital mortality in patients admitted for COVID-19. BACKGROUND AND AIMS: COVID-19 is a multi-system disease, with coagulation abnormalities. 1 Coagulopathy is common in critically ill patients with COVID‐19. D-dimer level of > 2.14 mg/L predicted in-hospital mortality with a sensitivity of 88.2% and specificity of 71.3% (AUC 0.85; 95% CI = 0.77–0.92). Background: Patients critically ill with coronavirus disease-2019 (COVID-19) feature hyperinflammation, and the associated biomarkers may be beneficial for risk stratification. Higher D-dimer levels were associated with a greater probability of pulmonary embolism 3, 6, 9, and 12 days after determining D-dimer levels with an OR of 1.7, 2.0, 2.4, and 2.4, respectively in 21 patients from Spain. We aimed to investigate the association between several biomarkers, including serum C-reactive protein (CRP), procalcitonin (PCT), D-dimer, and serum ferritin, and COVID-19 severity. D-dimer levels are increased in this disease. When you get a cut, your body takes a bunch of steps to make your blood clump up. 2.6. Differences of mean value of D-dimer between patients with severe disease and patients with non-severe disease, and odds of severe COVID-19 associated with D-dimer greater than 0.5 μg/ml, on admission, were defined as the outcome of the meta-analysis. We identified a product of N/L\*CRP\*D-dimer as having an important predictive value for the severity of COVID-19. A D-dimer test is a blood test that can be used to help rule out the presence of a serious blood clot. Statistical analysis 3 However, less is known about the coagulation parameter D‐dimer in the progression of COVID‐19. The cutoff value was 5.32. We aimed to determine the association of D-dimer levels and mortality and to establish its optimal cut off values in predicting mortality. D-dimer is commonly elevated in patients with COVID-19. Elevated D-dimer levels, while common with COVID-19, do "not currently warrant routine investigation for acute VTE in absence of clinical manifestations or … Our purpose is to determine whether there are differences between DD values in PE-positive and PE-negative COVID-19 patients and, if so, to establish a new cutoff value which accurately determines when a CTPA is needed. The negative predictive value of less than 5.32 for the N/L\*CRP\*D-dimer was 93.75%, while the positive predictive value was 46.03% in the test sets. The sensitivity and specificity were 89.47% and 67.42%. We aim to assess the use of D-dimer as a biomarker for disease severity and clinical outcome in COVID-19 patients. • A normal D-dimer (unusual in critically ill individuals with COVID-19) is sufficient to exclude the diagnosis of PE if the pretest probability for PE is low or moderate but is less helpful in those with a high pretest probability. D-dimers in predicting the occurrence of pulmonary embolism in patients with COVID-19. An increase in D-dimer is … With COVID‐19 determine the association of D-dimer levels and mortality and to establish its optimal cut off values predicting! 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